Occupational Exposure Limits for Enzymes: Practical Considerations
نویسندگان
چکیده
منابع مشابه
Extrapolating from toxicity data to occupational exposure limits: some considerations.
This paper evaluates procedures relevant to extrapolating from toxicity data in man and animals to Occupational Exposure Limits. It examines effects at or around the "No Observed Adverse Effect Level' (NOAEL) and the magnitude of safety factors which can be applied in developing occupational exposure limits for non-stochastic effects. The relationship between incidence of stochastic effect and ...
متن کاملOccupational exposure limits for chemicals.
Occupational exposure limits (OELs) are tools to help employers protect the health of those who may be exposed to chemicals in their workplace. Under the United Kingdom Control of Substances Hazardous to Health (COSHH) Regulations they define adequate control by inhalation. OELs are set by the Health and Safety Commission (HSC) on advice from its Advisory Committee on Toxic Substances (ACTS) an...
متن کاملOccupational exposure limits for therapeutic substances.
Few therapeutic substances have occupational exposure limits (OELs) set by regulatory bodies and reliance is often placed on in-house OELs derived from a formula based on the therapeutic dose. This mode of derivation relies on assumptions about pharmacokinetics, pharmacodynamics and risk acceptability which might not be soundly based for occupational health purposes. Pharmacodynamic evidence sh...
متن کاملSetting Occupational Exposure Limits: Are
Setting limits for safe exposure to toxic agents in the workplace is a complex process involving science, law, and policy. Development and use of occupational exposure limits (OELs) transcends national interests and international borders. Even though OELs have a lengthy history, and they form the cornerstone of most occupational risk assessment and risk management plans, their effectiveness in ...
متن کاملReassessment of occupational exposure limits.
BACKGROUND Although the Netherlands currently has its own procedure for evaluating chemical compounds and setting occupational exposure limits (OELs), most of these limits were originally adopted in the 1970s from threshold limit values (TLVs) set by the American Conference of Governmental Industrial Hygienists (ACGIH). However, beginning in the late 1980s, criticism about non-scientific consid...
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ژورنال
عنوان ژورنال: International Journal of Pulmonary & Respiratory Sciences
سال: 2021
ISSN: 2573-2234
DOI: 10.19080/ijoprs.2021.05.555651